A troubled psychiatrist turns investigator when a young patient confesses to murder. Psychiatrist Mark Angelotti knows that genes don't lie. Or do they? Back at work after a devastating illness, Mark believes he has put his past behind him when he is asked to examine Charlie Dickerson, a mentally handicapped teenager whose wealthy mother insists he is a victim of sexual abuse. Mark diagnoses a different reason for Charlie's ills, but his prescription turns deadly when a teacher is murdered and Charlie confesses to the police. Volunteering to testify on Charlie's behalf, Mark's worst fears are realized when paternity tests show the victim was pregnant with Charlie's child. Now it's up to Mark to prove Charlie's innocence in a case where nothing is as first meets the eye. Not even genes—Mark's or Charlie's—can be trusted to shine a light on the truth.

Blind psychiatrist Mark Angelotti has just enrolled in a drug trial that holds out hope of restoring his eyesight when he again becomes entangled in a case that is rocking the Chicago legal community. After defending the manufacturer of the powerful antipsychotic drug Lucitrol against product-liability claims, attorney Jane Barrett has become somewhat of an expert on the controversial medication. So when her lover, investigative journalist Rory Gallagher, collapses from a fatal dose of the same drug, it falls to Hallie Sanchez, Barrett’s oldest friend, to defend her on murder charges. Amid growing doubts about her friend’s innocence, Hallie recruits Mark Angelotti to help her discredit the testimony of a crucial eyewitness. The pair succeeds in obtaining Barrett’s release, but at a dreadful price. Mark sets out to investigate who else may have wanted the journalist out of the way. As he gets closer to the truth, he realizes the killer is still on the loose. But two questions remain for Will the drug trial succeed in restoring his eyesight? More important, will he live long enough to see this case to its end?

Blind psychiatrist Mark Angelotti is faced with his most troubling case yet when he is asked to evaluate Rachel Lazarus, the estranged wife of a slain University of Chicago professor. Months earlier, the professor’s body was found stuffed into one of the exhibits at “Scav,” the school’s world-famous annual scavenger hunt, and – in a feast for the press – missing a vital piece of its anatomy. Though she’s confessed to her husband’s murder, Rachel is mounting a battered woman’s defense. Forced into helping the prosecution, Mark becomes unsure of his objectivity when his investigation uncovers uncomfortable parallels between Rachel’s history and his own. That concern proves well-founded when his damaging admission at trial all but convicts Rachel. Then a tip connects the case to another suspected murder and evidence that Rachel may not be guilty after all. As he plows ahead during a brutal Chicago winter, Mark soon learns he has far more to worry about than treacherous snow and ice: someone will do anything to guarantee that Rachel takes the fall.