In this letter to Nicolas Toinard, esteemed English philosopher John Locke outlines his original method of organizing his common-place books through the use of a two letter consonant and vowel index system. It is here translated for the first time into English from the original French, and appended with a preface by Jean Leclerc, a treatise by Henry Oldenburg, and two letters of Doctor John Wallis on his efforts in teaching the deaf-mute how to speak.