The novel portrays the wayfarers August and Edevart's experiences while they travel around in Norway for more or less random work. The trilogy continues with August three years later, and concludes with The Road Leads On in 1933. The events in Wayfarers take place between 1864 and the 1870s. The entire trilogy describes the conflict between a traditional subsistence economy and a modern commercial and industrial society, as it emerged in Norway in the second half of the 1800s and the early 1900s. August is the main character that ties the three novels together.

I «August» (1930) er hovedpersonen, som Hamsun første gang hadde skildret i «Landstrykere» (1927), blitt en mann i slutten av 40-årene. Han er fremdeles den rastløse, oppfinnsomme og initiativrike prosjektmaker. Det er oppgangstider i bygda Polden. Et rikt sildefiske fører til pengerikelighet. Augusts entusiasme smitter over, og poldværingene selger sin matjord til byggetomter og kjøper aksjer i bank og fabrikk. Men det kommer dårligere tider. Silda uteblir, og på grunn av uheldige konjunkturer stiger matvareprisene. Augusts virketrang har ført poldværingene ut i dyp misère. Hele samfunnet kommer i ubalanse og trues av hungersnød og katastrofe.

They had met during their younger days, he and the widow of Theodore paa Bua. The original fusion of their passion had taken place during a golden opportunity out in the berry field—she had given him a certain look upon leaving the house and he had gone a round-about way and met her. Violence—violence and violation, but so welcome, so unimpeachable. Ay, and their affair had continued without interruption throughout two whole summers and one winter. When they parted, they had had good cause to remember each other and when they met again they had neither of them changed; they were the same mad lovers they had been during their earliest youth.