Anghelides' first published work was the short story "Moving On" in the third volume of the Virgin Decalog collections, which led to further short stories in the fourth collection and then in two of the BBC Short Trips collections that followed. In January 1998, his first novel Kursaal was published as part of BBC Books' Eighth Doctor Adventures series on books. Anghelides subsequently wrote two more novels for the range, Frontier Worlds in November 1999, which was named "Best Eighth Doctor Novel" in the annual Doctor Who Magazine poll of its readers, and the The Ancestor Cell in July 2000 (co-written with departing editor Stephen Cole). The Ancestor Cell was placed ninth in the Top 10 of SFX magazine's "Best SF/Fantasy novelisation or TV tie-in novel" category of that year. Anghelides also wrote several short stories for a variety of Big Finish Productions' Short Trips and Bernice Summerfield collections. This led, in November 2002, to the production of his first audio adventure for Big Finish, the play Sarah Jane Smith: Mirror, Signal, Manoeuvre. In 2008, he wrote a comic which featured on the Doctor Who website

is a freelance comic writer and author. He is best known for his work on a variety of spin-offs from both Doctor Who and Star Wars, as well as comics and novels for Vikings, Pacific Rim, Sherlock Holmes, and Penguins of Madagascar. Cavan Scott, along with Justina Ireland, Claudia Gray, Daniel Jose Older, and Charles Soule are crafting a new era in the Star Wars publishing world called Star Wars: The High Republic. Cavan's contribution to the era is a comic book series released through Marvel Comics titled Star Wars: The High Republic.