Christine Therese O'Donnell is an American Republican Party politician who founded two advocacy organizations and has been an advocate for nonprofit clients and nonprofit causes for nearly 20 years. A Tea Party favorite, and with strong financial support from the Tea Party movement, she defeated nine-term U.S. Representative and former governor Michael Castle in Delaware's September 2010 Republican primary for U.S. Senate. She lost the November 2010 U.S. Senate election in Delaware, to Democrat Chris Coons by a margin of 57% to 40%. O'Donnell's 2010 Senate run was her third try for the office in five years. In the Senatorial election of 2008, she was the Republican nominee, losing to the incumbent, Joe Biden, by 65% to 35%. In 2006, she ran in the Republican primary for Senate, finishing third, then ran as a write-in in the general election, drawing 4 percent of the vote. In addition to running for the Senate, O'Donnell has worked as a public relations and marketing consultant and has provided commentary on the Fox News Channel and CNN. She is a conservative on fiscal, social and political issues, including abortion and sex education.