Danny Wormwood is having all the troubles of modern man, his TV shows have issues, he cheats on his wife, and his rabbit talks back to him. But this poor sod also has to deal with the fact that his dad is Satan himself and Pope Jacko and the Catholic church are also raising Hell. Oh yeah, the Armageddon is about to start and Jesus is a right thicko, not much help there.

Danny Wormwood is back, and he's brought Jimmy the Talking Rabbit and Jay (formerly known as Jesus Christ, but worse for wear these days) with him! Since averting Armageddon in his last adventure, the world hasn't improved. Danny, the reluctant Anti-Christ, still produces questionable TV shows and pines for Maggie, his lost love. It seems the best these boys can hope for is a quiet drink at their favorite pub. However, the evil Pope Jacko will not let Wormwood rest after his last sound defeat! To dispatch the Anti-Christ once and for all, Jacko calls upon his deadliest Holy Assassin, Brther One the Killer Eunuch! More blasphemy, action, and razor-sharp dialogue by Garth Ennis, creator of PREACHER.

Danny has his hands full when his lovely girlfriend Maggie drops a huge surprise on him, and Jimmy the Rabbit gets into all kinds of things he really shouldn't. More troubling is the fact that Jay seems to be switching back-and-forth from being normal and kinda slow, all while the new forces of Hell are planting the seeds of Danny's destruction.

The recently-departed Pope Jacko is back in New York and turning it into a demonic infested Hell and he has finally crushed Danny's spirit and taken the life of one of his dearest friends!

Danny Wormwood is the Anti-Christ, his father is Satan, and his demonic powers help him fit right into New York's slimy television entertainment business. Danny's best friend is Jesus, the savior of humanity whose brain damage—a tragedy of mob violence—keeps him from performing miracles these days. There's a scheduled Armageddon coming right up, and an insane Pope out for Danny's blood. Can this reluctant Anti-Christ avert the apocalypse, withstand the forces of Heaven and Hell aligned against him, and keep his girlfriend blissfully in the dark from his true heritage? A tale of Armageddon and the Anti-Christ from Garth Ennis, the creator of PREACHER!