Cassandra Nova has murdered 16 million mutants. Now she has her sights set on The X-Men! Xavier and his team of mutants have long dreamed of a time of peace. But the time for dreaming is over. Now it is time to fight. Collecting: New X-Men (2001) 114-117, New X-Men (2001) Annual 1

As protesters lay siege to the Xavier Institute, Professor X lies in a coma, trapped within the shattered form of his evil twin, Cassandra Nova. Collecting: New X-Men (2001) 118-126

Collects New X-Men #122-126. As protesters lay siege to the Xavier Institute, mutant mentor Professor X lies in a coma, trapped within the shattered form of his evil twin! Cassandra Nova inhabited Xavier's body and escaped to the stars in the wake of her initial encounter with the X-Men; now, the psionically empowered psychopath is returning to Earth possessed of the most powerful mutant mind on the planet, and with the might of the Shi'Ar Imperium at her back! She brought an interstellar empire to its knees. Can even the X-Men hope to halt her mad rampage?

His name is Charles Xavier … and he is a mutant. For years, Professor X was widely regarded as an authority on genetic mutation, and an advocate of peaceful relations between man and mutant. The general public was unaware he possessed superhuman powers until the psionically empowered Cassandra Nova—his twin sister—addresses the global media while in possession of her brother's body and broke the decades-long silence. But in attempting to expose Xavier to his enemies, she unwittingly freed him from his self-imposed exile. From the teeming city streets of New York's Mutant Town to the irradiated ruins of the island nation of Genosha, once a haven for mutants, the X-Men set off to heal the rift between humanity and Homo Superior—only to discover a terrifying new threat from a new species! Collecting: New X-Men (2001) 127-133

To prevent the collision of our universe with another, the Illuminati must reassemble! to face an infinite legion of parallel realities. Armed with the six Infinity Gems, the Illuminati gather to plan for the death of everything…

Collects New X-Men #139-145. More secrets of the world's deadliest mutant are exposed! Wolverine, Cyclops and the enigmatic mutant known as Fantomex travel to the other side of the world and beyond in search of the keys to their pasts. However, what they find within the deadly Weapon X program may be more frightening than their worst nightmares!

Meet the X-Men from 150 years in our future. While some faces may seem familiar, readers will discover all-new heroes and villains for the first time. What incredible force threatens to destroy the mutants of the future, and how will it affect the X-Men of today? Collecting: New X-Men (2001) 151-154