Dave's a bit of a loser. Even he'd admit that was true. He's no good at relationships, he's a terrible employee, and he's got no clue what to do with his life. Quite frankly, the world doesn't seem to have a place for him. But that's okay, because the world's just about to end. An experiment thousands of miles away is about to initiate a world-wide apocalypse that's going to change everything. The world as Dave knew it is over, and he's going to find that the apocalypse has it in for him. While people all around him become infected by nightmarish creatures, Dave discovers he's got some friends left alive who need his help. Together, they're going to have to do battle with parasitic squid creatures out for blood, and find a way to survive an apocalypse designed to eliminate all human life.

Dave's still alive, and even he can't believe it. But the apocalypse is in full swing, and he's got a whole world full of squids to contend with if he's going to make it back to Gabby and the others. This time around he meets a few new "friends" he'll need to depend on to stay safe. Dave and his new friends will find themselves plunging deep into a mine to escape the Terrameds, but if they thought it'd be a safe escape then they're in for a rude awakening. There're more than just a few squids to fight this time!