Successful ER doctor Ward Thrasher uproots her life and her flourishing career in a busy Philly hospital to the mountains of Pennsylvania to follow her partner of 6 years, Dr. Jess Benson, another ER doc. But after a few months, they grow increasingly apart, especially after the death of Jess' mother from cancer, and eventually separate over a freak incident, though neither of them have officially called it quits. Ward still nurses a flame and can't bring herself to return to Philly. So she takes up temporary doctor duties in several hospitals near to Jess. A chance meeting with the CEO of one of them, Abby, brings romantic possibilities. But what about her unfinished business with Jess? Is Abby a temporary rebound romance? What chance does it have against a 6-year relationship? Meanwhile, a psycopath is on the loose. Not on the streets of Pennsylvania, but inside the halls of its hospitals. His MO is chillingly effective and virtually undetectable. Will he ever be discovered and stopped before he reaches his avowed goal of breaking all serial killer records?

After being kidnapped, Dr. Jessica Benson suffers from a case of post traumatic stress disorder that can’t be good for her drug habit. But how can she get the help she needs without risking her medical license? And why does she keep thinking about the sexy detective assigned to her case? Confirmed bachelorette Detective Mac Calabrese can’t help the attraction she feels for her star witness, but she’s professional enough to fight the attraction. Teaching Jess self-defense draws them closer, but can the clean-cut Mac handle Jess’s past history of drug abuse? And will the homicidal drug dealer Derek Knight put an end to their love before it even begins?