It is 1536 and the expert swordsman Jean Rombaud has been brought over from France by Henry VIII to behead his wife, Anne Boleyn. But on the eve of her execution Rombaud swears a vow to the ill-fated queen: to bury her six-fingered hand, symbol of her rumoured witchery, at a sacred crossroads. Yet in a Europe ravaged by religious war, the hand of this infamous Protestant icon is so powerful a relic that many will kill for it... From a battle between slave galleys to a Black Mass in a dungeon, through the hallucinations of St Anthony's Fire to the fortress of an apocalyptic Messiah, Jean seeks to honour his vow.

Years have gone by since the events surrounding the death of Anne Boleyn. But her missing hand and all that it represents to the dark world of 16th century Europe still draws the powerful to seek it out. Jean Rombaud - the French executioner of the first novel - has grown old, both in age and spirit. Wearied by the betrayal of a son and the scorn of a wife, he fights in the seemingly never-ending siege of Siena. Meanwhile, Gianni Rombaud has forsaken everything his ageing father stands for and now kills heathen for the Inquisition in Rome. Then he is summoned by Cardinal Carafa himself. His masters no longer merely want his dagger in the hearts of Jews, they want the hand of the dead queen.. But, only three people know where it is buried, and one of them is Gianni's father...