When Cordell Carmel catches his longtime girlfriend with another man, the act that he witnesses seems to dissolve all the boundaries he knows. In that instant, the calm existence of this middle-aged New York City man becomes something unrecognizable: he wants revenge, but also something more. Killing Johnny Fry is the story of Cordell's dark, funny, soulful, and outrageously explicit sexual odyssey in search of a new way of life. His guide is a mysterious woman named Sisypha, who leads him deep into the erotic heart of the city.