A new breed of criminal stalks the barrios„the Zavalas, part death-worshiping cult, part crime syndicate. The seductive and merciless Gemma Zavala, aka Mama Z, heads the cartel. Anyone she can't bribe or intimidate ends up paying the ultimate price as a human sacrifice in her Aztec rituals. Ruthless, blood-thirsty with influence far and wide, the Zavalas appear unstoppable. Until they murder the wrong girl...

Once more, Santa Muerta, the saint of death, calls upon Maria Diaz to be an instrument of vengeance. And again Maria heeds the call, donning the guise of La Muerta. Seeking justice for a murdered child, La Muerta narrowly escapes death at the hands of a supernatural evil: the legendary La Llorona. But La Muerta's victory is short-lived. Her defiancé has enraged a ruthless, criminal mastermind known as Brujo. Practicing the darkest of magic, Brujo will stop at nothing to accomplish his nefarious plans. Now, only La Muerta and the luchador vigilante Loco can challenge the crime boss' brutality. How can La Muerta fight an enemy she can't kill and what terrible price will she pay for the sake of retribution?