Mills Run, Ohio is not much different from any other small town. The residents have a bond and kinship. Nothing in the town is state-of-the-art, except perhaps the ferry. The townspeople brag that Mills Run is isolated, and at times, cut off from the rest of the world. However, not even Mills Run is secluded enough for a global pandemic. When an outbreak of H7N2, or as the news calls it, Whitby Fever, begins striking cats and dogs, it is newsworthy, but not panic-inducing. After all, instances of cross- breed infection with H7N2 are rare. Clare Ashton knew better, yet she was labeled insane when she tried to get the word out, until it is confirmed that Whitby Fever has crossed the boundaries, spreading from domestic pets to humans at an astronomical rate. The virus causes such a high fever, that the body succumbs in days. It is everywhere. The death rate is out of control. Mills Run is not immune and neither are the townspeople. Clare, like every other mother, sister, and daughter in the world, does her part to fight and help those around her who she loves. A face mask may be her armor, her good heart may be her shield, but there is no weapon to defeat the fever because there is no cure. Mother Nature rages a viral war against the world and Mills Run is one of the millions of battlegrounds fighting to live.

After emerging from a coma, Faye Wills opens her eyes to complete darkness and the feeling of being trapped. She awakens in the worst place imaginable, one of thousands of bodies in a makeshift mass grave that was once a football stadium. Left for dead, there are no signs of life and the only sound she hears is the buzzing of flies that follow the stench of death. Once out of the stadium she steps into a desolate, barren world, void of all life and people. Faye learns that while in a comatose state, the world was besieged by some sort of epidemic. Without a soul around, there are a lot of missing pieces. Where did everyone go? In her weakened state, she must pull it together and move forward to find answers and survivors. However, she soon realizes that she may never find anyone and must face the possibility that she may be The Last Woman on earth.

After losing her entire family in a tragic accident, Faye Wills follows a path of depression and alcohol abuse in an attempt to bury her pain. Her course of self-destruction places her in an alcohol induced coma. When she wakes, she discovers the world was besieged by a virus and she was left for dead on top of a mound of bodies in a football stadium. The world is a barren and desolate place and it works in Faye’s favor. With no desire to live, she sets a goal of making it home to die. Then she encounters Dodge and two young boys. They ignite a spark long lost in Faye. That spark is the will to live. Following radio calls, they decide to join a growing camp of survivors. Until they discover that not only is Faye a survivor, she is the last surviving woman on earth. Suddenly the rules change. Faye is no longer safe in the growing violent world. Marauders chase her and what is left of the government, actively seek her, stopping at nothing until they retrieve Faye. While trying desperately to find a haven for her, Dodge and the boys, Faye must also discover her place and role in a world without women. Weighing the decision of what she wants to do against what she should do. The continuation of man’s existence begins with Faye.