When Professor Xavier, the mentor of the X-Men, uncovers evidence of a planned secret alien invasion of Earth, he enlists the X-Men in a desperate race against time to find key pieces of technology to build a weapon powerful enough to stop the attacking forces.

Peter Parker, the amazing Spider-Man, has made an astonishing discovery-he has a sister! Unfortunately, a manipulative super-villain known as the Gentleman-who had a hand in the deaths of Peter's parents-has somehow brainwashed her into becoming the deadly supervilainess known as Pity! Together with Doctor Octopus, Electro, the Vulture, and Mysterio, they've formed the newest incarnation of the super-villain group dedicated to destroy Spider-Man, the Sinister Six! But there is something more than just the death of Spider-Man on the Sinister Six's agenda; something that has caused Col. Sean Morgan and his high-tech anti-espionage agents of S.A.F.E. to become involved. Spider-Man teams up with Morgan to stop the Sinister Six before they can put their world-threatening plan in motion, and to save his sister before it's too late!

First mass-market edition! Peter Parker, the amazing Spider-Man, has made an astonishing discovery—he has a sister! Worse, a manipulative super-villain known as the Gentleman, who had a hand in the deaths of Peter Parker's parents, has somehow brainwashed her into becoming the deadly super-villain known as Pity! Together with Doctor Octopus, Electro, the Vulture, and Mysterio, they've formed the newest incarnation of the super-villain group dedicated to destroy Spider-Man, the Sinister Six. The Gentleman's plan to destroy Spider-Man is about to reach its awful conclusion!

Hank McCoy—the X-Men's Beast—made himself a guinea pig in a desperate attempt to find a cure for the deadly Legacy Virus. His gamble succeeded. Now his blood is a living serum that can save countless lives. Unfortunately, the Beast is also a prisoner of Selene, the dread Black Queen of the New York branch of the Hellfire Club and she is literally bleeding him dry in order to further her own mad quest for power and wealth. The X-Men, and their uneasy ally, Sebastian Shaw, the mutant Black King of the Hong Kong branch of the Hellfire Club, are locked in a race against time to defeat Selene and free the Beast. But to their shock, they have discovered that Selene has found a way to turn time itself into a weapon against them. Meanwhile, Sebastian Shaw and the mysterious menace known as Mutant X, pursue a different agenda—one that if it succeeds, will place the Legacy Virus serum in the hands of the most dangerous mutant in the world!