Massimo Mattioli debuted in 1965 in the periodic comic book Il Vittorioso with Vermetto Sigh. He was also published in Corto Maltese. In the early 1970s, he created Pasquino for the newspaper Paese Sera. In 1973 he began his collaboration in the Il Giornalino, for which he created the character Pinky. In 1977, in association with Stefano Tamburini, he founded the underground magazine Cannibale. In 1978, Cannibale published the first adventure of Joe Galaxy. In 1980, he was one of the founders of the underground magazine Frigidaire with Stefano Tamburini, Andrea Pazienza and Filippo Scòzzari. In 1982, he created the series Squeak the Mouse, a parody of Tom and Jerry. Mattioli was awarded several prizes, including the French prize Phenix in 1971, the Yellow Kid in 1975 and the Romics d'Oro in 2009.