Going through "the change" isn't easy on any woman. Mood swings, hot flashes, hormonal imbalances, and itchy skin are par for the course. But for these four seemingly unrelated women, menopause brought changes none of them had ever anticipated—super-heroic changes. Helen discovers a spark within that reignites her fire. Jessica finds that her mood is lighter, and so is her body. Patricia always had a tough hide, but now even bullets bounce off her. Linda doesn't have trouble opening the pickle jar anymore…now that she's a man. When events throw the women together, they find out that they have more in common than they knew—one person has touched all their lives. The hunt for answers is on.

With great power comes…great frustration. Several months after the events of Going Through the Change, retired corporate vice president (and occasional lizard-woman) Patricia O’Neill is embroiled in a search for the mad scientist who brought the “change” upon them all . Meanwhile, Flygirl Jessica Roark and gender-bending strongman Linda/Leonel Alvarez have joined a mysterious covert agency known only as The Department. They’re training hard, in hopes of using their newfound powers for the greater good. Patricia thinks they’re being used. Cut off from the other menopausal heroes, she’s alone. And her search has hit a serious dead end. Then Patricia disappears, and all the clues point to a dead man. It’s up to her friends and The Department to find her and bring her home.