Miss Pickerell was mighty glad to be home from her vacation. She had had an overdose of noise and confusion. As she led her cow out to graze behind her little house she thought happily about the rest they were both going to have. But suddenly she saw, right in the middle of the pasture, the strangest, largest contraption she had ever laid eyes on. She was very frightened, but this was a clear case of trespassing. Miss Pickerell didn't hesitate. She went right up to investigate the outrage. What happens after that is more than she bargains for. It is a question who is most surprised: Miss Pickerell or the captain and the crew!

When the sheriff catches the measles Miss Pickerell takes over his hunt for Uranium

Imagine Miss Pickerell's indignation when she hears that her famous collection of rocks from Mars has gone down with the shipwreck of Liberty Bell!. Miss Pickerell's frantic efforts to recover the precious rocks involve not only a race between rival salvage companies - but Miss Pickerell finally has to put on a diving outfit and search for the wreckage herself! And with her usual spirit of adventure she is fascinated to learn all about deep-sea diving, atomic submarines, underwater television, sonar equipment. As usual, Miss Pickerell is straight wonder, but the scientific details are just as authentic and up-to-the-minute as modern findings can make them. And Paul Galdone's humorous drawings are again the crowning touch to an unpredictable Miss Pickerell adventure.

Miss Pickerell travels to the Arctic by snowmobile to rescue several scientists

A mysterious animal epidemic sweeps Square Toe County, and Miss Pickerell's beloved cow and a newly acquired kitten named Pumpkins are gravely ill. When known antibiotics fail to halt the disease, Miss Pickerell carries out a daring plan—one that takes her to the moon.

The heroine helps her friend Mr. Rugby in his latest project of ocean farming and tries to save it from failure

Miss Pickerell helps prevent a faulty weather satellite from bringing disaster to the inhabitants of Square Toe County

Miss Pickerell was trying to think of a name for her cow when the telephone rang and plunged her into a horrifying chain of events.

Miss Pickerell gets involved with cloned bulls, kidnappers and explaining scientific responsibility to the Governor and Mayors.

Earthquakes in a nearby county and the disappearance of three earthquake-prevention scientists bring Miss Pickerell on the run to tackle the crises.