In the last stages of a genetic disease, Ellen Creighton has decided to live out her remaining days at the estate of her longtime friend Harrison Burlington. Harrison cares deeply for Ellen, but as a wheelchair-bound paraplegic, he's never allowed himself to get serious in a relationship. However, he's desperately trying to save her by finding the holy water that is believed to heal any disease. When he locates two flasks, Ellen refuses to drink one of them because she believes the holy water killed her sister and father. In an effort to convince her to take it, Harrison ingests the contents first, and when Ellen witnesses the effects, she can no longer deny the power of the substance in the bottles. Dangerous criminals are also seeking the holy water, and Ellen soon learns they will go to any lengths to get the powerful drug—including sending her back into the past to find it for them.