It has been six months since the terrorist Rol-Hama had captured the world’s cryptids. The madman transformed the cryptids into giant monsters and then unleashed them on the world. Sea monster attacks quickly shut down worldwide shipping. The world’s economies and vital infrastructures are falling apart. Essential supplies that keep the world functioning including food, medicine, and oil are unable to be delivered. In response the US government enacts Operation MEG (Monster Extermination Group). The plan consists of mutating two great white sharks to monstrous proportions. Now the fate of world is in the hands of Operation Megalodon.