Everyone thought the world would end in a rain of atomic fire; no one suspected it would come from a piece of bad fish. An unidentified and aggressive illness begins spreading in North Dakota, and the nation panics. People are becoming sick, losing their minds, and murdering each other in disturbing ways. The government is struggling to come up with a solution, but as the epidemic mutates within the civilian population, its grip grows stronger. Dom is thousands of miles away near Seattle, witnessing his city collapse. The pandemic hasn't even reached them, but people are panicking and rioting as though it's already there. Holed up in his apartment with his best friend and girlfriend, Dom fears the worst. Dr. Adam Baker dreamt of a different life; one full of scientific discoveries and not a failed marriage and twin daughters who hate him. But when the opportunity to make a difference arises and his team has to find a solution to this national crisis, he finds that what he wanted is more than he bargained for. Who will survive in the wake of this devastation?

On the year anniversary of parasite Anisakis Nova’s first appearance, the infected launch a massive coordinated attack against cure distribution centers. In an instant, the already fragile country dissolves into chaos once again. The infected aren’t just back; they’re smarter and stronger than ever with world domination on their minds. Meanwhile, humans struggle to defend themselves against the infected onslaught. While some choose to recede into the mountains to start a new life, others fight to save civilization. For both, a nightmarish game of survival has only just begun.