BEFORE THE MANSION.BEFORE THE DISASTER. EVIL IS BORN. Sent to investigate a series of grisly murders in Raccoon City, S.T.A.R.S. Bravo Team scrambles into action. On the way to the scene, Bravo's helicopter crashes. Although everyone survives, what they discover next is gruesome: an overturned military transport truck riddled with corpses—and that's only the beginning of their nightmare. Bravo Team is about to discover the evil that is growing all around them, and rookie member Rebecca Chambers is beginning to wonder what she's gotten herself into.

Raccoon City: a remote mountain community suddenly besieged by a rash of grisly murders encroaching upon it from the surrounding forest. Bizarre reports start to spread, describing attacks from vicious creatures, some human... some not. Victims are apparently eaten. At the epicenter of these deaths is a dark, secluded mansion belonging to the mysterious Umbrella Corporation. For years umbrella has labored within the mansion, unwatched, ostensibly conducting benign genetic research. Deployed to investigate the strange goings-on is the Special Tactics and Rescue Squad (S.T.A.R.S.), an unusual paramilitary response unit boasting an eclectic assortment of mission specialists: roguish Chris Redfield, former cat burglar Jill Valentine, dead-eye Barry Burton, and the enigmatic team leader, Albert Wesker. Together with the other S.T.A.R.S. operatives, they have a good reason to believe they're ready for anything. But what unfolds as the S.T.A.R.S. penetrate the mansion's long-locked doors is terror beyond their worst nightmares: creatures that defy the laws of life and death—the result of forbidden experiments gone disastrously wrong. Behind it all is a conspiracy so vast in its scope and so insidious in its agenda that the S.T.A.R.S. will be betrayed from within to ensure that the world never learns Umbrella's secret. And if any survive... they may well come to envy those who did not.

In the aftermath of their ordeal through the Umbrella Corporation's genetic research facility, the surviving members of the Special Tactics and Rescue Squad (S.T.A.R.S.) attempt to warn the world about the conspiracy to create terrifying biological weapons. But the conspiracy is far from dead, as the S.T.A.R.S. learn when they are declared outlaws by the very people who trained them. Forced to go underground, the S.T.A.R.S. resolve to battle the conspiracy on their own, determined to seek out and stop Umbrella's experiments wherever they may be. Combat medic and biochemist Rebecca Chambers, the sole survivor of Bravo Team, joins a new S.T.A.R.S. strike force when rumor comes of another Umbrella experiment: hidden beneath the rocky cliffs of Caliban Cove, Maine, someone is building an army of the undead. Within a sinister lighthouse, through a complex maze of sea caves, inside the shell of a sunken shipwreck, the S.T.A.R.S. must battle more unspeakable horrors and stop a madman from unleashing the biohazard upon the world. But the S.T.A.R.S. may never get the chance, as the aggressive DNA-altering virus Umbrella has engineered to create its living weapons begins to infect them...

Leon Kennedy, a rookie cop on a new assignment, and Claire Redfield, sister of the still-missing S.T.A.R.S. member Chris, arrive at Raccoon City to discover a necropolis. A botched attempt by the Umbrella Corporation to retrieve a devastating mutagenic weapon has resulted in a horrifying viral outbreak, transforming the city's population into the living dead. And all of them are hungry.

Umbrella has begun to lose control of its hidden research facilities. Three labs have already been destroyed. But beneath the deserts of the American Southwest, one of the company's most elaborate facilities is about to go online.

Zombies. Mutant animals. Bioengineered weapons and surgically enhanced monsters. Secret labs and widespread conspiracies. It seemed impossible, but Kill Valentine and her teammates among the S.T.A.R.S. had seen it all firsthand when the Umbrella Corporation turned Raccoon City into a staging ground for the most insidious genetic experiments ever conceived. After all she's been through, Valentine is ready to leave that remote mountain community forever. But Umbrella isn't finished with Raccoon City. Too much evidence of their unethical and immoral research still exists. It must be recovered or destroyed—and quickly—before it can be traced back to Umbrella. And with William Birkin's mutagenic virus already spreading through the city like wildfire, drastic measures are needed. Under cover of night, mercenary teams have entered the city, along with something else—Umbrella's failsafe: an evolved version of its Tyrant-class killing machines, a lethal creature code-named Nemesis. Now Nemesis is on the hunt. And Jill Valentine is about to become prey.

A desperate search for her missing brother once again pits Clare Redfield against the terrifying bio-weapons of the Umbrella Corporation. Her quest leads her to a remote island where a mad genius has unleashed every grotesque creature at his disposal to prevent her interference.