Tired of boring sex and wanting to expand her pleasure, 24-year-old Amanda "Mandi" Wilkinson enrolls in summer school at San Francisco Sex University, an exclusive sex school located in the heart of San Francisco. What Mandi doesn't realize is that not all of the mysterious dropouts are simply flunking sex-ed. Reed McAllister came to Sex U. for reasons all his own. Undercover, he's searching for a woman, the right woman, and so far he doesn't have any leads. Reed never saw himself working at a place such as SFSU, let alone instructing, but he had to admit it - the job did come with its perks. When Mandi turns up on the missing list, will Reed be able to save her and give her the lessons she so desires?

Raised by an over-controlling and manipulative father, Savannah "Van" Morgan flees the East Coast for the West, seeking sanctuary with her Aunt Lucy, headmistress of San Francisco Sex University. Rather than staying at the main campus, Van enrolls in SFSU's more nurturing "sister" school, the All-Girls Academy. After visiting the main campus of SFSU, Margaret "Maggie" O'Neil hangs up her police badge in search of new experiences, hoping to awaken her sex-starved body. With subject matters such as an "Art Sex-education" class with an Italian visiting professor who's more than happy to schedule private tutoring after-hours, the All-Girls Academy invites all sorts of sexual exploration. In the end, will Van and Maggie fall victim to the pressures of society or come together to save each other?