Tall, thin, androgynous Shirley Combs considers herself the world's greatest living detective because she uses the methods and casebook of Sherlock Holmes to solve crimes of the gentry of the American city most closely resembling London, England—in terms of the weather, at least. Sidekick/narrator Dr. Mary Watson both delights in and is frustrated by her partner's behavioral resemblance to Sherlock. Combs is unemotional, analytical, and given to pacing through the night in the streets of the almost perfectly livable city of Portland, Oregon. Her ability to observe details and understand their relationship to a case is unmatched; her demands on Watson's time are too.