Margins
Singularities book cover
Singularities
Landmarks on the Pathways of Life
2001
First Published
3.81
Average Rating
274
Number of Pages
Erwin Schrödinger's What is Life? published 60 years ago, influenced much of the development of molecular biology. In this new book Christian De Duve, Nobel Laureate and pioneer of modern cell biology, presents a contemporary response to this classic, providing a sophisticated consideration of the key steps or bottlenecks that constrain the origins and evolution of life. De Duve surveys the entire history of life, including insights into the conditions that may have led to its emergence. He uses as landmarks the many remarkable singularities along the way, such as the single ancestry of all living beings, the universal genetic code, and the monophyletic origin of eukaryotes. The book offers a brief guided tour of biochemistry and phylogeny, from the basic molecular building blocks to the origin of humans. Each successive singularity is introduced in a sequence paralleling the hypothetical development of features and conditions on the primitive earth, explaining how and why each transition to greater complexity occurred.
Avg Rating
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Author

Christian de Duve
Author · 5 books

Christian de Duve (1917-2013) was a Belgian scientist and author. He discovered the cellular components called lysosomes and peroxisomes and researched insulin and glucagon. He was jointly awarded the Nobel Prize in Medicine in 1974 with Albert Claude and George E. Palade "for their discoveries concerning the structural and functional organization of the cell". Born outside of Belgium, de Duve and his family returned to Belgium when the First World War ended, having fled the country for this reason. He started studying medicine in 1934 at the Catholic University of Leuven and graduated in 1941. Being a gifted student, he started working in the laboratory of professor J.P. Bouckaert who was trying to uncover the mechanism of action of insulin. Believing the answer could be found in biochemistry, de Duve started studying chemistry and graduated in 1946. He was awarded a doctorate in 1945 for his doctoral thesis "Glucose, Insuline et Diabète". He became a professor at the Catholic University of Leuven in 1951 and later at the Université Catholique de Louvain (UCL). He started working at the Rockefeller Institute (now Rockefeller University) in 1962 dividing his time between Belgium and the United States. He also worked at the Medical Nobel Institute in Sweden and the University of Washington, USA. He founded the International Institute of Cellular and Molecular Pathology (now known as the de Duve Institute) in Brussels in 1974. He became emeritus professor in Belgium in 1985 and in New York in 1988. He wrote several books on the origin of life and biology.

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