At the behest of a deadly benefactor known only as the Gentleman, the Chameleon must assemble a new Sinister Six: Dr. Octopus, the Vulture, Electro, Mysterio, and the Gentleman's mysterious ward, Pity. But Mysterio, the master of illusion, has a plan of his own! A number of Hollywood people have been targeted for murder, and the Webhead must halt Mysterio's deadly rampage before more lives are claimed.

Peter Parker, the amazing Spider-Man, has made an astonishing discovery-he has a sister! Unfortunately, a manipulative super-villain known as the Gentleman-who had a hand in the deaths of Peter's parents-has somehow brainwashed her into becoming the deadly supervilainess known as Pity! Together with Doctor Octopus, Electro, the Vulture, and Mysterio, they've formed the newest incarnation of the super-villain group dedicated to destroy Spider-Man, the Sinister Six! But there is something more than just the death of Spider-Man on the Sinister Six's agenda; something that has caused Col. Sean Morgan and his high-tech anti-espionage agents of S.A.F.E. to become involved. Spider-Man teams up with Morgan to stop the Sinister Six before they can put their world-threatening plan in motion, and to save his sister before it's too late!

First mass-market edition! Peter Parker, the amazing Spider-Man, has made an astonishing discovery—he has a sister! Worse, a manipulative super-villain known as the Gentleman, who had a hand in the deaths of Peter Parker's parents, has somehow brainwashed her into becoming the deadly super-villain known as Pity! Together with Doctor Octopus, Electro, the Vulture, and Mysterio, they've formed the newest incarnation of the super-villain group dedicated to destroy Spider-Man, the Sinister Six. The Gentleman's plan to destroy Spider-Man is about to reach its awful conclusion!