It begins with the murder of a New York socialite. Following the trail of the killers, Spider-Man is soon confronted by one of his oldest, deadliest enemies; the Lizard! Once a respected scientist, Dr. Curt Connors created a serum that he hoped would regenerate the arm he has lost years before. But the serum did more than regrow his arm—it turned him into a savage, human-hating creature called the Lizard! Spider-Man pursues the Lizard from the concrete canyons of new York to the lush jungles of Mexico. Once there, he discovers that the Lizard is not only formulating a new plan to wipe out all humans, but he now has an army of reptilian creatures ready to carry out his orders! Spider-Man faces the fight of his light as he attempts to defeat his arch enemy and escape the...Valley of the Lizard.