Kara Zor-El has seen some epic adventures over the years, but finds her life without meaning or purpose. Here she is, a young woman who saw her planet destroyed and was sent to Earth to protect a baby cousin who ended up not needing her. What was it all for? Wherever she goes, people only see her through the lens of Superman’s fame. Just when Supergirl thinks she’s had enough, everything changes. An alien girl seeks her out for a vicious mission. Her world has been destroyed, and the bad guys responsible are still out there. She wants revenge, and if Supergirl doesn’t help her, she’ll do it herself, whatever the cost. Now a Kryptonian, a dog, and an angry, heartbroken child head out into space on a journey that will shake them to their very core.

After the shocking conclusion of last issue, Supergirl and her new friend Ruthye find themselves stranded with no way to pursue Krem, the murderous kingsagent. Each moment this fugitive roams free, the more beings become dangerously close to dying by his hand. There is no time to lose, so our heroes must now travel across the universe the old-fashioned way…by cosmic bus! Little do they know, their journey will be a dark one filled with terrors that not even the Maid of Might is prepared to face! Can Kara Zor-El lie low long enough to ensure their safe passage?

Supergirl’s journey across the cosmos continues! Her hunt to bring the killer Krem to justice brings her and the young alien in her care to a small planet, where they discover that there are still some very small minds, even on the outer edges of the galaxy. The cold welcome the locals give the Woman of Steel makes her suspicious enough to go looking for secrets they want to keep buried, and what she finds is nothing short of horrifying. Can she and Ruthye get off the planet alive now that these deadly sins have been exposed?

Supergirl sets her sights on the Brigands, a group of dastardly nomads hell-bent on slaughtering all they come across. Nowshe must follow their path of destruction to find the fugitive they've been hiding who set her on this intergalactic journey in the first place!