Chris Sprouse was born in Charlottesville, Virginia. At the age of 3 he moved with his family to New Delhi, India where he first discovered comics as he was unable to play outside due to the dangerous amount of snakes in the house yard. When he was 6, his family returned to the United States to Dale City, Virginia, where he continued to read and draw comics. Before his debut in comics, Sprouse drew a comic strip entitled "Ber-Mander", for the school newspaper ("The Hyphen"), while attending Gar-Field Senior High School in Dale City, Virginia. After graduating in 1984, Sprouse attended James Madison University where he studied graphic design. Sprouse launched his career in mainstream comics in 1989, his first credited work being a Chemical King story in an issue of DC Comics' Secret Origins. He then did a Two-Face story for Batman Annual #14 and then moved on to the limited series Hammerlocke. Sprouse then took on the sci-fi series Legionnaires, featuring teenaged versions of the characters in the Legion of Super-Heroes series, and eventually moved on to a number of one-shot and fill-in issues before illustrating a Star Wars mini-series, Splinter of the Mind's Eye, for Dark Horse Comics. He then worked for Extreme Studios as the regular penciller of New Men, and in 1997, Sprouse drew several issues of Supreme, scripted by Alan Moore for the same publisher. After Supreme ended, a year later he and Moore created Tom Strong for America's Best Comics, for which Sprouse won two Eisner Awards in 2000, for Best Single Issue and Best Serialized Story. Sprouse was also the penciller and co-creator on the 2004 Ocean mini-series, written by Warren Ellis and published by DC Comics. In 2007, Ocean was optioned for film. In 2006, he began pencilling Wildstorm's Midnighter ongoing series, a spin-off of The Authority. He has also been announced as the artist on the first issue of Batman: The Return of Bruce Wayne with Grant Morrison as writer. Sprouse currently lives in Columbus, Ohio with his wife, Xan.