After escaping their imprisonment from Plum Island, Griffin and Jarrod return to the mainland only to find that a second outbreak of the virus has ravaged the entire country. Only this time, something has changed. Help is not on the way. Their only chance of survival is to get back to Dr. Oswald in Florida, where a unique Altered child could hold the key to a cure for the Infected. Even if Griffin can find his way home, it may be too late to save mankind from its extinction event. This time, everyone’s luck may run out for good.