As Rodimus commands the starship Lost Light in search of the legendary Knights of Cybertron, a suspicious transmission leads Ratchet, Drift, and Pipes to the Autobot medical facility Delphi. The 'bots are unwittingly exposed to a plague that's ravaging the hospital. The only clue to the plague's origins is an explosion that occured not long after two Decepticons came seeking refuge. While the Delphi medical team of First Aid, Ambulon, and Pharma try to save a dying Pipes, the two Decepticons attack - but the Autobot called Fortress Maximus chooses that moment to emerge from a several-years-long coma... and he's not happy.