For years they investigated the paranormal, pursued the "monsters of the week," and sought the truth behind extraterrestrial activity, along with the grand conspiracy surrounding it rooted deep within their own government. But when Agents Mulder and Scully reunite for a new, ongoing series that ushers The X-Files into a new era of technological paranoia, multinational concerns, and otherworldly threats, it'll take more than a desire "to believe" to make it out alive. Collects issues 1-5.

As Scully and Mulder try to deal with the fallout from the actions of a mysterious group that has been targeting anyone associated with the X-Files and causing their return to the Bureau, reports that a creature from their past has returned sends Mulder heading to Martha's Vineyard and Scully to Quantico. Collects issues 6-10.

Fox Mulder and Dana Scully are back investigating the X-Files. Contains issues #16–20 and the stories "Immaculate," "Monica & John," and "G-23."