Reagan, Pepper, and Lily have just moved into their first apartment on Vickery Circle. Getting used to living with two women who are not as tidy and punctual as she is, is something Regan will hopefully learn to get used to. On top of moving, starting a new job, and constantly fighting with her boyfriend Isaac, a new guy enters into Reagan's life, who she is instantly drawn to. Not only is he causing Reagan to question her relationship with Isaac, but he's also Pepper's boyfriend. Vickery Circle follows the lives and loves, of three individual women with vastly different personalities as they deal with conflict, laughs, and tears, while they try to navigate through this new life of being a “responsible adult.” Together they discover that although life can be challenging, they will always have each other to lean on.