In 2033, former soldier Vlada Stoia becomes the first human to successfully merge with alien DNA. She gains heightened physical abilities and arms formed from resilient alien flesh. Less than a year later, a meteor shower strikes Keign, Illinois, unleashing hostile Apophids—the source of the alien DNA. As the quarantined city descends into chaos, a military task force is deployed to eradicate the threat. Vlada joins the operation, battling both the Apophids and visions from her tormented past.