Two small-time thugs are hired to transport a caged werewolf cross-country. But when the werewolf escapes, their lives are on the line if they can't find the lycanthrope and get the beast back in his cage.

George and Lou used to be thugs for hire. Now they're living in a shack in Costa Rica, hiding from the crime lord who wants them dead. Their last job, to deliver him a werewolf in a cage, went...badly. But they can't hide out forever, and when they're finally captured, it seems as if George and Lou's ultimate fate will involve being doused in gasoline and set aflame. Instead, they're given a second chance. There's another werewolf out there. This time, it's Ally, a fourteen-year-old girl. Kidnapping a teenaged girl is a major conflict with George and Lou's moral code, but they also aren't fans of being brutally executed, so they agree to the job. After all, the crime lord doesn't want to kill Ally—he just wants her to bite him. They'll snatch her, deliver her as promised, and then do everything they can to return her home safely. She doesn't even know she's a werewolf; it's not as if she'll create any complications by transforming. Of course, this is George and Lou, so there are many, many complications. The worst of which is that they've now enraged three other extremely nasty werewolves...

Though still mourning his recent loss, George Orton is surprisingly content. He's living in a secure compound where teenaged werewolf Ally is being trained to control her animalistic tendencies, and mad science experiment Eugene has regained most of his sanity. George knows they can't stay there forever, but for now, things are pretty good. Then he receives some shocking news: people at the compound have brought his partner and best friend Lou back to life. Not as a flesh-eating zombie; he's the old Lou, as much of a wiseass as before. But this comes with a great big string attached: George and Lou must take a cross-country road trip to kill Asher Anderson, a cloak-wearing lycanthrope who would love to see a war between humans and werewolves. Does everything go wrong? Of course it does. This is George and Lou. But they won't travel alone. Because Lou isn't the only one who was brought back to life...