"Unmanned (Part I of V)" Written by Brian K. Vaughan (Lost, EX MACHINA), this is the saga of Yorick Brown - the only human survivor of a planet-wide plague that instantly kills every mammal with a Y chromosome. Accompanied by his pet monkey, Yorick searches for his lost love...and the answer to why he's the last man on earth.

When a mysterious plague kills all male life on the planet, what do women do with the billions of corpses? Yorick Brown discovers the horrific answer as he travels to Washington in search of his Congresswoman mother. And which unexpected female has just been named President of the United States?

Trapped inside an impenetrable bunker, Yorick Brown struggles to rescue his Congresswoman mother from a murderous posse. Meanwhile, Culper Ring operative Agent 355 risks her life to protect the first female President of the U.S., and the news that a lone male has survived begins to leak out...

In this emotional issue, Yorick joins hundreds of women at a famous monument to pay tribute to all of the men who died in the Plague. But when a pack of violent female extremists interrupts this memorial service, the last man on Earth may end up joining his fallen brothers...

Yorick and Agent 355’s search for the one woman who may be able to save the human race comes to a close, but with a less-than-happy ending. Elsewhere, one of Yorick’s closest friends takes a horrific first step towards becoming the last man on earth’s greatest enemy.

In this perfect jumping-on point for new readers, Yorick Brown and his companions embark on an important quest. Riding the rails across a radically transformed America, the last man on earth is pursued by several competing factions, including the deadly Daughters of the Amazon.

Yorick Brown arrives in the seemingly utopian town of Marrisville, Ohio. But what terrible secret are its residents hiding and how far will they go to protect it? Meanwhile, the trail gets hotter for the last man's bloodthirsty pursuers, and the situation grows more dire for Yorick's friends.

In the mysterious town of Marrisville, the last man on Earth may have finally found true romance. Unfortunately for Yorick, it's not with his beloved girlfriend, who's still trapped on the other side of the planet! Elsewhere, Agent 355 reveals a shocking secret…

“Cycles” reaches its explosive conclusion with a sibling's madness, a firefight with a stolen helicopter, and a mysterious Russian carrying urgent news. All this, plus a truly startling development from Earth's orbit.

Yorick Brown is the last man on Earth…but is he the last man in the solar system? That question is raised when a mysterious visitor lands on top of Yorick’s speeding train. Plus, the identity of the shadowy informant is finally revealed.

As a Soviet escape vehicle leaves the International Space Station, chaos erupts below. Five women risk their lives to make sure that Yorick Brown, the only man on Earth, is not the last. And the terrifying, true motivation of Yorick’s foreign pursuers is finally revealed.

The fate of the two male astronauts who’ve been trapped in space is finally revealed, and the unmanned world will never be the same. Plus, Yorick Brown has one last confrontation with his foreign pursuers, and Agent 355 reveals her true feelings for the young man that she’s vowed to protect.

In part 1 of the 2-part “Comedy & Tragedy,” find out what art and entertainment might be like in a world without men. The female performers of the Fish & Bicycle Traveling Theater Company are doing what they can to carry on, but what could their work have to do with the last man on Earth?

It’s opening night of the all-female Fish & Bicycle Theater Company’s controversial new play. But if a mysterious visitor from Japan gets her way, the show may have the shortest run in the history of modern drama. When the curtain finally falls, will anyone be alive to see it?

Travel inside the mind of the last man on Earth! What is Yorick Brown’s deepest, darkest secret, and what does it have to do with a swarm of New York City houseflies? One very domineering woman intends to do whatever it takes to find out—whether Yorick likes it or not!

What really happened to Yorick Brown in the first days after the Plague killed every other male on earth? Find out, as this psychosexual journey through the memories of the last man comes to a haunting end.

Yorick, Agent 355, Dr. Mann and Ampersand hit the road again on their way to San Francisco, but a pit stop in Arizona finds them face-to-face with an anti-American (and heavily-armed) militia made up of female survivors who believe that the U.S. government is responsible for the death of all men.

It’s guns, alcohol, and a monkey as the last man on Earth’s standoff with the female survivors of an Arizona militia group continues. Yorick grows closer to one particular member—and Dr. Mann reveals a horrific secret.

The last man on earth’s confrontation with the female survivors of a violent militia group comes to an end. Plus, an unexpected guest arrives, and the status quo of the unmanned world is forever changed.

Yorick arrives at a church to meet the caretaker, a former flight attendant coincidentally named Beth. Feeling confessional, the pair bare their souls and confess their various "sins"...and then some!

Part 1 of the 5-part "Ring of Truth"! At long last, Yorick, 355 and Dr. Mann make their way to San Francisco to find out what caused the plague. But Yorick's unbalanced sister and the mysterious Setauket Ring have also made their way west—and they all have plans for the last man on earth!

As Yorick fights for his life, Dr. Mann and Agent 355 attempt to figure out why he survived the plague and whether the mystical Amulet of Helene played any role.

It's a dysfunctional family reunion when Yorick is reunited with his sister Hero. Will they continue their deadly rivalry—or has the ex-Amazon seen the error of her vicious ways? Plus, a mysterious ninja, a monkey and a shocking revelation that'll turn the series on its ear!

"Ring of Truth" reaches a shocking conclusion! Just when Dr. Mann finally discovers the answer to how Yorick and Ampersand survived the mysterious plague, an unforeseen adversary swoops in and steals a major key to the possible cure. But could the thief be working for someone close to the trio?

Finally leaving the United States, Yorick and his companions begin an important quest for a missing friend. Yorick joins a ragtag band of female sailors on a thrilling voyage overseas, but what dangerous new threat lurks deep beneath the Pacific?

Written by Brian K. Vaughan. Illustrated by Goran Sudzuka. Mature Readers The explosive conclusion of the 4-part "Girl on Girl." The good ship Whale makes its final stand against the crew's heavily-armed pursuers, and countless women meet a watery grave. Will any of Yorick's companions survive? Plus, a woman from Yorick's past makes a startling reappearance.

Series co-creator Pia Guerra returns for a special stand-alone issue that finally reveals the whole story behind Yorick Brown's long-lost true love, Beth Deville. As Yorick risks his life to travel halfway around the world in search of this alluring young woman, Beth must survive her own trial by fire.

At long last Yorick and his companions finally reach Australia in the first part of a new arc titled "Paper Dolls." However, as he begins his search for Beth, the last man encounters a dangerous and unexpected new adversary!

Brian K. Vaughan's award-winning series continues in "Paper Dolls" Part 2! A journalist threatens to expose Yorick Brown's existence to the world, a move that could easily destroy Yorick's chances of ever finding his finance Beth!

Explore the past, present and future of Ampersand, the long-lost pet of the last man on earth! How did this male monkey end up with Yorick Brown, and where has the animal been since he was kidnapped by a mysterious Japanese assassin?

Beginning the all-new arc, "Kimono Dragons!" The last man and his companions finally reach Japan in search of Ampersand, Yorick's long-lost pet and the key to mankind's return. They're one step closer to learning who or what killed all the other males, but how many of Yorick's friends will live to hear the answer?

Hot on the trail of Ampersand the monkey, Agent 355 and Yorick make a startling discovery in Tokyo, while Dr. Mann and her new girlfriend are confronted by a very unexpected figure from the doctor's past. "Kimono Dragons" Part 2!

After last issue's origin of Dr. Mann, this issue takes a look at the "secret origin" and untold story behind former Israeli Defense Forces leader Alter Tse'elon. What drives this female soldier's hunt for the last man on Earth, and what will Alter find that could mean the end of Yorick Brown?

"Motherland" part 1! Beginning an all-new story arc that sees Yorick Brown and Agent 355 preparing for their ultimate quest to reunite the last man with Beth, and Dr. Mann traveling to China to finally find the person—or people—responsible for the global gendercide.

With the long-awaited revelation of who or what caused the plague that killed every man except for Yorick Brown, will new life be created or old ones snuffed out? "Motherland" part 3.

"Whys and Wherefores" part 1, the final arc of the series begins here! Boarding the Trans-Siberian railroad for France, Agent 355 escorts Yorick Brown on the last leg of his quest to find his one true love.

Yorick Brown has been searching for his lost love for years. Now as the series races toward its conclusion on the dangerous streets of Paris, will the last man finally enjoy a long-awaited reunion? 'Whys and Wherefores' part 3.

Only three issues left before the explosive, emotional and exciting conclusion to Y: THE LAST MAN. And as the series itself draws to a close, so does Yorick Brown's journey of love. 'Whys and Wherefores' part 4.

Series finale! It's the dramatic conclusion you've been waiting for as Yorick Brown and company reach the end of their journey in this very special double-sized issue!