As Reed faces bankruptcy and Ben—the Thing—experiences great personal turmoil, they, along with Sue and Johnny, must fight to protect the world against supervillains including Diablo, Super Skrull, and the Grey Gargoyle.

Having embarked on the ultimate journey. Reed, Sue and Johnny must contend with the defenses of the afterlife - and storm the gates of Heaven itself to rescue their fallen teammate. They've faced the destroyer of everything, Galactus. Now, they face the creator of everything, as the Fantastic Four are reunited in the Hereafter.