His war has been won. The few humans left alive are enslaved, the mutant rebellion crushed. En Sabah Nur, the Apocalypse, rules his Battleworld kingdom without mercy, but the terrorist X-Men plan to end his reign. Success means finding one very special mutant named Cypher and unleashing a weapon that will kill Apocalypse...and possibly all mutants, too!

The philosophy of Apocalypse has always been "let the fittest survive," but by its ultimate extension, that would only leave one person standing! As mutants fall from the shocking release of a devastating plague, who will live and who will die? And if Apocalypse falls, who will rule in his place?