Falling in love is a chemical reaction. Just ask Kaya Rubio, twenty-five year-old Molecular Genetics graduate student and research assistant. Fed up with her spinster aunts' relentless reminders and unsolicited advice regarding her Single Since Birth status, she designs a scientific, evidence-based methodology to find her a suitable partner in time for her cousin's wedding. As any good scientist knows, any valid experimental design requires a negative control. Enter the most unsuitable candidate for a potential boyfriend: the messy, easygoing, café owner Nero Sison. Her null hypothesis? Going out with Nero would establish her baseline data without catalyzing the chemical reaction she seeks. But when Kaya's recorded results refuse to make sense, she is forced to come to the conclusion that there are some things in life that are simply, by nature, irrational and illogical. And that sometimes, chemistry doesn't always happen inside a lab.