The shaman "Lizard" is one of the two-souled-ones, a Berdache. He must convince his proud and stubborn childhood friend, the warrior Red Wolf, that he, too, is a Berdache and must take the shaman training, before Red Wolf loses his mind. A call for aid comes, so the Berdache, Red Wolf, and the beautiful Chickasaw slave, Born In Moonlight, take the journey to hopefully avoid a war. Will these three give into the closeness they begin to feel or will they be forever separated by the dangers they face from both the Spirit World, and the world that surrounds them.