An all-new original story! From the celebrated imagination of Dean Koontz comes a powerful reworking of one of the classic stories of all time. If you think you know the story, you know only half the truth. Welcome to the mystery, the myth, the terror, and magic of Dean Koontz’s Frankenstein. While healing from a beating she suffered at the hands of Victor Helios—once Dr. Frankenstein—and her own maker, Erika Five decides to leave the comfort of her glassed-in porch and bottle of cognac to go exploring into Victor’s secret home lab, which she believes is an antechamber to something more sinister. With the help of the bodiless head Karloff and his disembodied hand, Erika finds a secret lab and within sees experiments revealing Victor’s attempts to do more than create a race of super-immortals… and a mirror-like portal to another universe, one of infinite realities Victor is trying to bridge for his own horrible reasons!

Dean Koontz continues this all-new modern reimagination of the classic horror tale Frankenstein, created exclusively for comics! As Hurricane Shelley sends refugees fleeing like rats, Victor Frankenstein discovers that his portal to an alternate dimension has been used... and decides that the captive, animated head of Karloff must suffer for keeping its secrets. Meanwhile, Erika Five explores a whole new world, one with its own Karloff to question, a doppelganger just as treacherous as his namesake. Will Victor's true motives stand revealed?

The Resurrection Engine has fulfilled Victor's latest dreams of power, raising an army from the dead amidst the flood waters of Hurricane Shelley. But are these charred creatures truly at his command? Meanwhile, Carson and Michael face the undead hordes at the 13th ward, and Erika continues to interrogate the severed head of Karloff about the full extent of Victor's machinations.

The gale force winds and floodwaters have devastated The Big Easy... but the undead hordes unleashed by Victor Helios will tear the city down at its foundations! Meanwhile, Frankenstein's first creation Deucalion has his monstrous fingers at Erika's throat, while Carson and Michael attempt to figure out what drives the zombie army to their fearsome purpose!

As the risen dead rampage through New Orleans like locusts, police detectives Carson O’Connor and Michael Maddison finally track down the source of the undead uprising – Victor Frankenstein! But can two detectives really stop a city on the verge of death?

New Orleans has been overwhelmed by Victor Frankenstein’s risen dead. Now, just three of his own creations remain to stop him—an artificial woman called Erika 5, a bodiless head called Karloff, and a monster called Deucalion. Can they possibly overcome their own natures and end Frankenstein’s evil?