Emergency room surgeon Lukas Bower decides to leave the city for a small-town hospital and finds more trouble than he expected.

Dr. Lukas Bower is assigned to head his hospital's emergency room and must cope with medical, political, and economic crises, while his interest in Mercy Richmond alters as her ex-husband becomes converted.

Compassion draws together the lives of Dr. Lukas Bower and Dr. Mercy Richmond, as Lucas struggles with the unique challenges of working in a tiny rural clinic and Mercy struggles to balance her duty to her work and the needs of her daughter.