When Roland Doyle wakes up with a dead woman in his motel room, the only clue is a mysterious vial of pills bearing the label "Take one every 4 hrs or else." Ten years before, six people were involved in a secret pharmaceutical trial that left one of them murdered and five unable to remember what happened. Now the experiment is continuing, as Dr. Sebastian Briggs wants to finish his research into fear response and post-traumatic stress disorder. He's backed by a major drug company and an ambitious U.S. Senator, but he also has a personal stake in the outcome. Only by taking the mysterious pills can the survivors stave off the creeping phobias and inflicted madness that threaten to consume them. But the pills have an unexpected side effect-the survivors start remembering the terrible acts they perpetrated a decade ago. They are lured back to the Monkey House, the remote facility where the original trials took place, and Briggs has prepared it for their return. Now they are trapped, they each have only one pill left, and cracks are forming in their civilized veneer. After the pills are gone, there's only one option. "Or else."

The phone call isn?t the first threat Dr. Alexis Morgan has received. Not by a long shot. It is, however, the first time she escaped the taunting voice only to find her neurobiology lab at the University of North Carolina being raided. Alexis thought she and her husband, Mark, were finally moving beyond the horrors of the Monkey House, sight of the notorious, top-secret drug trials for a powerful personality-altering drug that stole so many innocent lives? But now Alexis' research into the drug's effects has caught the attention of a shadowy government agency anxious to use the drug for its own nefarious purposes. When people begin dying, Alexis knows it is only a matter of time before the men behind the conspiracy try to silence her. She and Mark flee into the mountains of North Carolina, seeking refuge with the other survivors from the Monkey House. There, as government agents close in, the survivors must also battle the demons within their own minds if they hope to keep the drugs out of enemy hands.