“You should not have answered its call...” Professor Stephen Barlow is no longer a skeptic. Having faced the horrors of Chaythe Asylum, he turns his attention to the man responsible for the Third Ward Incident—the enigmatic Dr. Corvine—in the hopes of finding answers to his many questions. But some things, he soon learns, are better left lost to history. Traveling to a remote cabin in Michigan in search of the doctor and his research, Stephen finds himself descending deeper into a world of terror and madness. He and his students uncover the frightful truth about Corvine's experiments and realize that they may have unleashed something terrible in their meddling.