Catwoman, Poison Ivy and Harley Quinn are tired of playing by other people's rules, regardless of which side of the law they're on. These tough ladies have a new agenda that's all their own and they'll use any means necessary to pursue it. With the Bat away, these sirens will play, and no one—not Hush, the Riddler or the Joker—knows what to expect from the bad girls of Gotham City. Only, sometimes friends can be more trouble than they're worth. Especially when they're unaccustomed to things like loyalty...or sanity.