Jess makes good on his promise to Juan Hernandez to bring in the evil murderous Mexican outlaw called Machete and hand his head over to the Mexican government. His job is tough enough, tracking him through New Mexico Territory, but once he sees the carnage Machete leaves behind, he wants to catch Machete and bring him to justice in the worst way. His job is hard enough, but he soon learns that Machete has a faithful flock of followers who believe his every word and would take a bullet for him to keep him safe. His job becomes even more complicated when he finds out that Machete's flock of followers are made up primarily of young men and even a few young women. Jess has to find a way to finally get to Machete without killing the young men and women in his flock, but they keep getting in his way, forcing him to consider doing some things that almost makes his quite the job of hunting Machete. The thought, however, of leaving Machete to roam the New Mexico Territory, murdering and butchering innocent women, forces him to continue his hunt for Machete knowing full well that he might have to kill some of his flock, who seem to be brainwashed and have no apprehension about giving their young lives for Machete.