Vincent Pike always had an aversion to sunlight, one that required him to take pills so he could live a normal life in New York City. But when a date goes horribly wrong, he soon discovers that this sickness is because of his vampire heritage. In a matter of hours, Vince finds himself befriended by a woman who calls herself a Nightweaver, a special kind of vampire with lethal powers. This woman claims that Vince is not only a vampire, but a powerful one known as a Blood Lord. With the powers of a Blood Lord, Vince can form his own coterie of supernaturals. He can make them more powerful through a tantalizing vampiric ritual, but he can also benefit by acquiring some of their abilities. But the arrival of a fabled Blood Lord to NYC won’t go unnoticed. Powerful groups like the Helsing Agency have their eye on Vincent, and if there’s one thing they don’t want, it’s to share power over the city, let alone the world.

After defeating Constantin and acquiring the Helsing HQ for his own, Vincent Pike is on the top of the world. But all that is threatened when he receives a visit from his Uncle Richter. Richter claims that Vince's parents are not only witches, but they are also in danger. Throw in the threat of rival blood lords and hordes of zombies, and things start to really heat up for Vincent Pike, Blood Lord of New York City. But if he can handle the heat, and come out on top, he might just find himself the ruler of all crypts on the East Coast.

Vincent Pike and his coterie set their sights on Miami. Another Blood Lord has taken control of the region, and it’s Vince’s intention to become the Blood Lord of the whole East Coast. But Vince’s ambitions won’t stop there. His thirst for power is much like his thirst for blood: insatiable. With this insatiable drive, it won’t be long before Vincent Pike’s quest for domination turns international.