Blossom, Bubbles and Buttercup are in Mojo Jojo's clutches! Their only hope is...the Professor? Uh-oh! Professor Utonium misses his Girls they're too busy fighting crime to spend time with him. So he invents a superhero suit and starts fighting crime along with 'em! At first everything's great...until the Professor starts taking on criminals all by himself. Can the Girls put a lid on his enthusiasm...before Mojo Jojo does?

The chalk monster drawings Bubbles has made are coming to life, causing touble for the girls' teacher Ms. Keane

Buttercup would rather watch Amazonia, the new cartoon superheroine, than fight evil, and she even imitates Amazonia's imaginary powers, so her sisters, Blossom and Bubbles, are unable to prevail against Mojo Jojo's evil scheme.

As leader of the Powerpuff Girls, Blossom begins to let the power go to her head, but her sisters know how to give her a reality check before it's too late.

The Powerpuff Girls are throwing a costume party. They have their costumes picked out and have invited all their friends. But just when the Girls start having fun, some super-evil villains decide to crash the party. Now it's the Girls against the villains—in the Powerpuff's own backyard! Can the Girls save the day, and themselves?

Uh-oh . . . The Powerpuff Girls' least favorite kindergartner has a new plan up her pricey sleeve. Princess Morbucks' big bucks can buy her a lot of the pretty things that Bubbles loves—and Princess is planning to cash in on the sweetest Powerpuff's one weakness! Now she's trying to bring Bubbles over to the dark side. And if she succeeds . . . she just may become the fourth Powerpuff Girl!

Something very strange is happening at Pokey Oaks Kindergarten. The Powerpuff Girls' super-sweet teacher Ms. Keane has suddenly become... Ms. Meane! Now it's up to The Powerpuff Girls to save their classmates from her evil clutches. But first they'll have to figure out which of Townsville's villains is behind this pernicious plot.

An all-new, original adventure starring Blossom, Bubbles, and Buttercup!