Four astronauts have returned from the moon...changed. Fury's hip-deep in a new conspiracy—but the only kind of conspiracy he likes is one he creates...So what's he going to do now that new super heroes are appearing all around America?

Meet this teenage outcast has found herself endowed with spider-like powers. Elsewhere, Ultimate Nick Fury learns why four astronauts returned to Earth transformed, and Nighthawk takes this opportunity to make his dramatic return!

As Ultimate Nick Fury assembles his new Squadron Supreme, the four mutated Icarus One astronauts go to...Las Vegas? Meanwhile, teen misfit Arachnophilia comes face-to-face with one of the missing Squadron members...

The crew of the Icarus One was changed forever in space. Then they did the one thing good government employees never they went public. Now standing between these four mutated astronauts and a firing squad is Ultimate Nick Fury!

America—devastated in a war of superhumans, abandoned by her greatest heroes...and rebuilt by Nick Fury. Now, the master manipulator will face a few old friends—friends who have some interesting ideas about the world of tomorrow.