Commander Benjamin Sisko is just recovering from the death of his wife when he is assigned command over the former Cardassian, but new Federation space station, Deep Space Nine. This space station is strategically located not only because of its orbit about Bajor, but also because of its proximity to the only known stable wormhole in the galaxy. After meeting the other Bajoran and Starfleet personnel assigned to the station, including a former Bajoran freedom fighter and a shapeshifter, Sisko finds himself in that very wormhole and in the midst of a metaphysical experience as the alien inhabitants of the wormhole question the concepts of time and love. Sisko, filled with humanistic hubris, begins to explain these experiences, and resolve his painful past.

Death prowls the passageways of Deep Space Nine. When Deep Space Nine is forced to curtail entry to the wormhole due to increased graviton emissions, an air of biting tension settles over the station. But when this anxiety leads to the murder of an Edeman religious leader, Commander Benjamin Sisko and Security Chief Odo realize they face a larger problem. The missionary is only the first to die; soon Sisko and Odo have more lifeless bodies on their hands and a killer who strikes without motive. Then, both the Edemans and the Cardassians arrive threatening to destroy the station unless the murderer is given to them for retribution. Now in order to save Deep Space Nine and stop the killing, Odo must try to destroy a powerful assassin who is the only link to his mysterious past.

Starfleet Command has learned that the Cardassians are planning to construct a base on the other side of the wormhole to establish a presence and claim the rich unexplored territory. Now, it falls to Commander Sisko, Major Kira, and the crew of Deep Space 9 to set up a Federation station there immediately. Before Major Kira can deliver the new base, a fanatic from her violent past appears. Kira must engage in a life and death struggle with an enemy who will stop at nothing to destroy her, as the fate of Bajor, the wormhole, and possibly the entire Federation hangs in the balance.

When Quark holds a poker tournament on Deep Space Nine someone from almost every sentient race—Klingons, Cardassians, Romulans, Vulcans, Ferengi—shows up for what is sure to be the highest-stakes game of all time. But when one player is killed, the stakes get higher than even these big-money players had counted on. With the station rocked by subspace waves that threaten its destruction, Commander Sisko and Security Chief Odo must hunt down the killer in time to save the players, a killer who has information that can save those on board Deep Space Nine from the invisible enemy they do not even know they face, a killer who holds all the cards.

When a troop of alien warriors demands the return of an imprisoned comrade—a prisoner no one on Deep Space Nine knows anything about—Commander Benjamin Sisko has a deadly fight on his hands. Under sudden attack from the heavily armed warriors, Sisko and his crew struggle desperately to repel the invaders and save the lives of everyone on board. Meanwhile, a strange device from the Gamma Quadrant has shifted Ferengi barkeeper Quark and Security Chief Odo three days into the future to a silent Deep Space Nine. To save the station they must discover what caused the invasion to take place, and find a pathway back through time itself.

When terrorists threaten a conference of Federation ambassadors, Commander Benjamin Sisko must defuse a deadly situation before the terrorists destroy Deep Space Nine and the entire planet Bajor.

A message left behind by the Kai Opaka gives Commander Benjamin Sisko a fateful mission: find a young Bajoran girl destined to be a great healer who could bring together the warring factions of Bajor. While Lt. Dax tries to find the healer, Dr. Bashir goes planetside to treat a rare disease that is killing the children in Bajor's resettlement camps. Surrounded by thousands of dying children, Bashir goes A.W.O.L. from Deep Space Nine, vowing not to return until the plague has been stopped. But by the time Dax finds the girl from the Kai's prophecy the child has fallen victim to the plague. Now, with the fate of the entire planet at stake, Commander Sisko must find Dr. Bashir in time to save the child who may be Bajor's last chance for peace.

The Bajoran shipyard is assigned to build an engine for a new starship, a project which could be instrumental in revitalizing the planet's war-ravished economy. As Commander Sisko awaits the arrival of a tanker containing the antimatter that will power the starship, a band of hijackers captures the extremely valuable cargo and escapes through the wormhole. When the hijacking spurs a political debate, Major Kira struggles to mediate the dispute between the opposing factions. Meanwhile, Sisko makes a desperate move to retrieve the antimatter. With the stability of the Bajoran economy at stake, Sisko, Dax, and Odo infiltrate the hijackers, a move that could have deadly consequences for them and the planet Bajor.

The Dominion: The mysterious rulers of the worlds on the other side of the wormhole. The Dominion: a ruthless planet-conquering race unknown even to those they rule. The Dominion: the most dangerous foe the Federation may ever face. At the edge of the wormhole, the space station Deep Space Nine™ and the planet Bajor sit on what will be the front line in any Dominion attack. To try and prevent the conflict, Commander Benjamin Sisko ant his crew take a never-tested Federation warship through the wormhole to track down and confront the Dominion. If Commander Sisko fails, not only the Federation, but the Klingons, Romluans, Cardassians, and all the worlds of the Alpha Quadrant will face an interstellar war they cannot win.

Political tensions on Bajor are once again on the rise, and the various factions may soon come to open conflict. In addition, a series of murders has shaken everyone on board the station. While Security Chief Odo investigates the murders, Commander Sisko finds himself butting up against a new religious faction that plans to take over Bajor and force the Federation to leave Deep Space Nine. Odo soon traces the murders to a bizarre and dangerous form of holosuite technology—a technology that turns it's users into insane killers and now threatens Sisko's son, Jake. As the situation on Bajor deteriorates, Sisko learns that the political conflict and the new holosuites are connected. Both are the work of a single dangerous man with a plan that threatens the very fabric of reality. The plot is darker than anything Sisko has faced before, and to defeat it, he must enter the heart of a twisted, evil world where danger lurks in every corner and death can come at any moment—from the evil within himself, from his closest friends, or even at the hands of his own son.