In a post-apocalyptic underwater dome, there lives a girl with a starfish growing from her head. Her name is Ohime. She is the starfish girl. Alone in this world, Ohime must fight for her life against lecherous crabmen, piranha people, and a yellow algae that is causing humans to mutate into fish. Until she meets Timbre, a woman with deadly sea anemone hair. Ohime thinks she is safe with her new protector and friend, but Timbre is on the run from a violent past. Now they must escape Timbre's former master, the evil Dr. Ichii, who is determined to conquer the underwater dome . . . and destroy the starfish girl and her friend in the process.